Hamp added that Lions ownership was considering the terminations for weeks but the past few games “had a lot to do with it.”
The firing came two days after the Lions lost to the Houston Texans on Thanksgiving Day 41-25, which dropped the Lions record to 4-7 on the season.
Darrell Bevell will serve as the Lions’ interim coach for the final five games of the season, Hamp said.
Patricia led the Lions to a 13-29-1 record since taking over in 2018. He joined the team after serving as the New England Patriots defensive coordinator for six years.
Quinn joined the Lions as the general manager in 2016. The Lions had a 31-43-1 record during his tenure as general manager.
The team’s last playoff appearance was in 2016.
Hamp said the Lions will do an “extremely thorough and comprehensive search” for who will fill in the two positions, but nothing has been decided.